Case-cohort study on PFC levels in maternal blood and the risk of child ASD, ADHD and CP.

Design:
A case-cohort design within the DNBC will be used to examine if PFCs in maternal blood are associated with infantile Autism Spectrum Disorders (ASD), Attention Deficit Hyperactivity Disorder (ADHD) or Cerebral Paresis (CP). From the Danish registries we have recorded approximately 200 cases of ASD, ADHD and CP in the cohort. 400 samples from the cohort will be used as controls for all the case groups. The comprehensive data collection in the DNBC permits detailed confounder control for social, medical, and environmental exposures at baseline and in early childhood.

Scientific team:
Responsible leader
Professor Jørn Olsen, Unit of Epidemiology, Department of Public Health, Aarhus University
Associates
PhD ASD-ADHD-CP student Zeyan Liew, Environmental Health Sciences & Epidemiology, School of Public Health, University of California (UCLA), Los Angeles
Professor, director Eva C. Bonefeld-Jørgensen, Centre of Arctic Environmental Medicine, Department of Public Health, Aarhus University
Subcontractors
Professor Beate Ritz, Department of Epidemiology, School of Public Health, University of California (UCLA), Los Angeles
Post Doc Chunyuan Fei, National Institute of Environmental Health Science, Biostatistics Branch, North Carolina
Senior Scientist Rossana Bossi, National Environmental Research Institute (NERI), Department of Atmospheric Environment, Aarhus University